You are studying a gene that encodes the major histone acetyltransferase enzyme

Question

You are studying a gene that encodes the major histone acetyltransferase enzyme in neurons. You've identified cells that homozygously express a conditionally mutant allele that is temperature-sensitive. The enzyme has normal activity at temperatures below 380C but the enzyme is nonfunctional at temperatures above 380C.

Identify the consequences of the mutation. Select all correct answers.

In neurons growing at 37 degrees, the mutant enzyme will cause histones to be evicted but this will not occur at 40 degrees.

if neurons are growing at 37 degrees the mutant enzyme would remove acetyl groups from histones

transcription activation in neurons will decrease as the temperature is raised from 37 to 40 degrees.

at 40 degrees histones in the neurons will be under-acetylated compared to at 37 degrees

the mutant enzyme will cause histones to be more tightly bound to the DNA in neurons growing at 40 degrees compared to 37 degrees.

In neurons growing at 37 degrees, the mutant enzyme will cause histones to be evicted but this will not occur at 40 degrees.

if neurons are growing at 37 degrees the mutant enzyme would remove acetyl groups from histones

transcription activation in neurons will decrease as the temperature is raised from 37 to 40 degrees.

at 40 degrees histones in the neurons will be under-acetylated compared to at 37 degrees

the mutant enzyme will cause histones to be more tightly bound to the DNA in neurons growing at 40 degrees compared to 37 degrees.

Explanation / Answer

I believe the correct options to be

D) at 40 degrees histones in the neurons will be under-acetylated compared to at 37 degrees

and

E) the mutant enzyme will cause histones to be more tightly bound to the DNA in neurons growing at 40 degrees compared to 37 degrees.

because HAT enzyme acetylated DNA so that it can be available for transcription otherwise which is bound to DNA.

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