please need help for this immunology question 7. In 1845, a group of Dutch immig

Question

please need help for this immunology question

7. In 1845, a group of Dutch immigrants emigrated from Europe to South America. Within two weeks of their arrival, an epidemic of yellow fever killed 50% of them and six years later epidemic of yellow fever killed another 20% of them. Thereafter, the mortality rate e low and the survivors remained in South America and intermarried (i.e. married o immigrants). Recently, the profile of MHC alleles in the descendan Dutch survivors was analyzed and compared to the MHC profile of European Three particular MHC class I allele frequency in the South Americ a brief explanation for this observation. (6 pts) was relatively ther Dutch ts of the South American Dutch people. s (B13, Bw38 and Bw50) were found at a much higher an descendants than in the European Dutch population. Provide

Explanation / Answer

In the South American descendants MHC class I genes, B13, Bw38, and Bw50 were more. This means that these alleles were present in the South American population.

Note that few emigrants migrated from Europe to South America. Let us consider that 100 people migrated. Out of these 100, 50 died due to yellow fever. 20% of 50= 10 further died of yellow fever. So, the left over population was 40.

These 40 people interbred with South American population. MHC genes of South American population and the European Dutch will be different. So, on two different chromosomes different haplotypes will be made. These haplotypes have come from South American people.

The haplotypes of European Dutch will be totally different. Note that the given MHC alleles, i.e. B13, Bw38, and Bw50 are present in the South American population initially (before emigration) and not in the European Dutch population.

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