Complete the sentences below using the words and phrases on the left, and then a

Question

Complete the sentences below using the words and phrases on the left, and then arrange the sentences in paragraph order to review the steps of translation Drag the text blocks below Into their correct order. stop (or nonsense) codon 5' methylated cap In prokaryotes, initiation begins at the eukaryotes, initiation begins at the 5 mehylated cap of the mRNA transcript h A site into the P site AUG is the first TRNA-readable" codon for the polypeptide chain; the tRNA that binds methionine (Met) oukaryotes E site Initiation ends when the initial charged tRNA is in place in the P site of the fully assembled ribosome. ribosome binding site A site During elongation, ongation factors usher charged tRNAs matching the mRNA codons one at a time into the ribosome's (TMe) The ribosome travels along the mRNA, moving the tRNA from the In this site, a peatide bond is formed between the amino acid the tAINA is carrying and the growing polypeptide chain. P site A site into the E ste After its amino acid is linked to the growing chain, the now-uncharged IANA is moved nto the release factor from which it is released from the mRNA P site into the A site Termination oocurs when a ston.for nonsensel sodon is reached. No tRNA matches this codon, and a release factor enters the A site, bringing about dissociation of the ribosome and release of the completed polypeptide peptide bond et

Explanation / Answer

In prokaryotes, initiation begins at the ribosome binding site of the mRNA transcript. In eukaryotes, initiation begins at the 5’ methylated cap. AUG is the first “tRNA-readable” codon for the polypeptide chain; the tRNA that binds to it carries N-formylmethionine (fMet) in prokaryotes, or methionine (Met) in eukaryotes. Initiation ends when the initial charged tRNA is in place in the P site of the fully assembled ribosome. During elongation, elongation factors usher charged tRNAs matching the mRNA codons one at a time into the ribosome’s A site. The ribosome travels along the mRNA, moving the tRNA from the A site into the P site. In this site, a peptide bond is formed between the amino acid the tRNA is carrying and the growing polypeptide chain. After its amino acid is linked to the growing chain, the now uncharged tRNA is moved into the E site, from which it is released from the mRNA. Termination occurs when a stop (or nonsense) codon is reached. No tRNA matches this codon, and a release factor enters the A site, bringing about dissociation of the ribosome and release of the completed polypeptide.

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