5. Cells t are growing/proliferating need to produce NADPH for biomolecular synt

Question

5. Cells t are growing/proliferating need to produce NADPH for biomolecular synthesis. One route of NADP synthesis is via the oxidative To fuel the pat pentose-phosphate pathway (OPPP), which is outlined in the accompanying figure. erti PPPpathway, glucose units (in the form of glucose-6-phosphate) are shuttled from glycolysis into the OPpp. The products of the OPPP, in addition to NADPH, are circled in the figure. These products can bre directly inserted back into glycolysis and be aerobically oxidized. How many molecules of ATP (theoretical maximum) are lost when glucose, diverted from glycolysis to the OPPP, is used to generate 6 molecules of NADPH? EXPLAIN your answer. (Note, in the fig of lines in an arrow represents the number of molecules reacting in one turn of 3 G6P to 3 CO, 2 F6P, and 1 GAP. (4 points) the pathway so as to convert NADPH+ H NADPH+ co OPO NADP H-C-OH OH H glucose HO ?1-0 H-C-OH6-phospho. gluconate glucono lactonase H OH HOH dehydrogenase Glucose-6 phosphate (G6P) 6-Phospho- genase Ribulose-5- 6-Phosphoglucono- 8-lactone phosphate (RuSP 2OH HO-C-H transketolase) H-C-OH ribulose-5-phosphate CH2OPO3 Ribose-5 phosphate (RSP) H-C-OH CH20PO32 Glyceraldehyde Sedoheptulose-7 3-phosphate phosphate (57P) CH2???? CH20H (GAP) ??-c-n ribulose-5-phosphate epimerase H-C-OH 7 transaldolase CH20PO Xylulose-5- phasphate (Ku5P) HO-C-H ?? H-C-OH H-C-OH H-C-OH transketo CH20PO-1 Fructose-6 Glyceraldehyde % phosphate ., 1,2-phosphate, CH20Po2 CH20PO32- CH2OPO32- Fructose-6 phosphate (F6p) Ervthrose-4- phosphate (E4P) Figure 1 4: Fundamentals of Biochemistry, 2e 2006 John Wiley & Sons

Explanation / Answer

Glucose to glucose 6 phosphate use one ATP molecule.
Glucose + ATP ---Hexokinase-------- Glucose 6 P + ADP + Pi
One glucose 6 phosphate produce 2 molecule of NADPH. So for 6 molecule of NADPH 3 molecule of ATP require.
Because 3 molecule of Glucose 6 P required to produce 6 molecule of NADPH.

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