Due 3/26 in class as a printed copy B3 Sp2018 Homework bioenergetics /enzymes ro

Question

Due 3/26 in class as a printed copy B3 Sp2018 Homework bioenergetics /enzymes rogenase (PDH) is a critical regulatory point of aerobic energy metabolism. It is regulated though a process of phosphorylation/dephosphorylation shown in the diagram. H20 Phosphorylation is the covalent addition of a Phosphate molecule to a substrate. The phosphate is added to PDH by the enzyme "PDH kinase". So, the action of POH kinase inactivates PDH. ??? PDH ATP - Dephosphorylation is the removal of the kinase from the POH active substrate. The phosphate is removed from the inactive PDH by the enzyme "PDH phosphatase". So, the action of PDH phosphatase re-activates PDH pyruvate CO CoASH a) Let's consider an imaginary drug called "substance X" You observe that there is more AcetylCoA produced by PDH in the cell when substance X is added to cells. Substance X does not affect the structure or activity of PDH. Explain 2 ways by which substance X may affect acetylCoA production by PDH. (3 pts) 1) 2) b) Explain two ways phosphorylation can prevent the activity of PDH. (3 pts) 1) 2)

Explanation / Answer

The imaginary drug Substance X may affect (increase as per the question) acetyl Co A production by PDH in the following ways-

b) Phosphorylation of PDH occurs generally at E1 sitePhosphorylation will inhibit PDH by

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