Pyruvate carboxylase (EC 6.4.1.1) catalyzes the carboxylation of pyruvate to for

Question

Pyruvate carboxylase (EC 6.4.1.1) catalyzes the carboxylation of pyruvate to form oxaloacetate, an intermediate in several metabolic pathways. Complete parts (a), (b), and (c) below. The net reaction is pyruvate + CO2 + ATP+H2O ? oxaloacetate+ADP+Pi+2H (al What is the role of ATP in this reaction? O It allosterically activates the enzyme. O It is the source of the phosphoryl group in the product.Oxaloacetate does not O It activates CO2 (HCO3 O It activates the enzyme cofactor. contain a phosphoryl group. (b) Identify the atom on the cofactor that acts as a nucleophile and reacts with the carbon dioxide. Click on the atom to highlight it. The selected atom will be highlighted green. (H atoms are not graded.) NH The name of the cofactor is thiamine pyrophosphate continued below

Explanation / Answer

Pyruvate carboxylase catalyzes the carboxylation of pyruvate to form oxaloacetate.
In this reaction, ATP allosterically activates the the pyruvate carboxylase.
Option a is the answer.

Pyruvate carboxylase uses biotin as cofactor.
The given molecule is biotin.

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