Questions regardingSthe Watson and Crick article from Nature, April 25 1953 1.Wh

Question

Questions regardingSthe Watson and Crick article from Nature, April 25 1953

1.What was the purpose of this paper?

2.Contrast the features of the Watson/Crick model to the three features of the Pauling/Corey model.



3.Using your own words, tell how the two chains are held together as explained in the paper.



4.According to Watson and Crick, which specific pairs of bases can bond together?


5.What do they say about the sequence of the bases?


6.Why doesn’t the model work if ribose is used in place of deoxyribose?


7.What do they say the specific pairing of bases suggests?

April 25, 1953 NATURE 737 equiprosur, and to De C. E. R Doanon and the captain of R.R.R angle of 16 Metween making the observatieok of Phosphorus arem the outsile, hava aay aenae to them. expect th MOLECULAR STRUCTURE OF together. Purina and Tyrinkii The of NUCLEIC ACIDS A Structure for Deoxyribose Nucleic Acid Item so the two lin by Eidin with idawskaal of the pai must be Purine Position for arid haa beer by Paulina and Cowy". To our opinion found that only of and Kher chain, then together engewiAlly as be thymine to be norrmirted in any However sisted by Fraser in the Bres then the sevence other mentaly that the ratio do t unity be repaded wing. of the details of the results mainly thoaga the dyad the xtruettare, inclding the it, togecher with for the oloma. will be publihed and roughly

Explanation / Answer

1) the aim of the paper was to find the structure of dsDNA Molecules..!!

3) the two chains are held together by the hydrogen bonds.!!

4) G combines with C with triple bonds. While A combines with T with double bonds.. Hence purine combines with pyramidine..

5) the ribose molecules contains a 2'-OH Molecules in them which causes a steric hindrance in forming a stable duplex DNA molecules and can create a problem in base pairing and dna stacking..

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