CsrA activation leads to breakdown of glycogen to glucose in addition to regulat

Question

CsrA activation leads to breakdown of glycogen to glucose in addition to regulating motility/infection.

a. Does it make sense for organisms to couple metabolism to surface adhesion and infection?

b. Why have one signaling pathway control both adhesion and metabolism instead of having one system to control adhesion and a separate system to control metabolism? What is one benefit of this approach? One drawback?

Reading reference: http://science.sciencemag.org/content/sci/suppl/2017/02/15/355.6326.735.DC1/Katsowich.SM.pdf (copy and paste in the address or the URL bar)

& Host cell attachment elicits posttranscriptional regulation in infecting enteropathogenic bacteria

Explanation / Answer

A. This is basically a stress reponse so CsrA activation leads to flagellar expression and motility and and downregulation of biofilm formation and glycogen synthesis. So these two process regulated by CsrA in response to stress.

b. Because upon stress the motility of the bacterial cell decreases and that will also prevent the glycogen synthesis because in stress response it is needed to take energy from glycogen breakdown and save energy from stopping the motility and form the biofilm. That is why these two process are inter related.

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