Q 1: Why are biofilms often resistant to treatment with antibiotics?What is a po
ID: 223687 • Letter: Q
Question
Q 1: Why are biofilms often resistant to treatment with antibiotics?What is a possible alternate target for an antibiotic to treat a biofilm? Q 2: ow is a disk diffusion assay performed? How does this test differ from E-test strips? Q 3: What are the five possible mechanisms of antibiotic resistance? Indicate if each is a result of a phenotypic change or a mutation (or both). Q 4: mproper use of an antibiotic can result in a superinfection. Explain how this can happen and what a superinfection is. How could the antibiotic treatment have been changed to avoid the superinfection? Q 5: List at least 4 desired characteristics of antimicrobial drug? why is each important? Q 6: What factors can affect microbial death rate? how does each impact death rate? Q 7: he availability of anti-fungals and anti-virals is limited. Explain why this is. Give an example of each, its mode of action and its target. please i need to know the correct answers. please help me.
Explanation / Answer
Ans 1 Microbes attached to biofilms are more resistant to antibiotics as compared to those alive. It is due to the fact that the biofilm provides a penetration barrier due to which the antimicrobials are unable to reach the microbes.
They are two alternate treatment strategies to treat such biofilm microbes, the first one focuses on targetting the biofilm forming the process of bacteria. Small molecules amd enzymes have been formulatee to disrupt this biofilm formation.
The other group focuses on modification of biomaterials that are used to make resistant biofilms.
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