CQ15: Below is a 5\' exon/intron junction: AAAGIGUAAGCGU f the G at the 5\' spli

Question

CQ15: Below is a 5' exon/intron junction: AAAGIGUAAGCGU f the G at the 5' splice site is mutated, and the downstream GU is used instead, which of the following would be true? A. The resulting protein would be two amino acids longer B. The resulting protein would be two amino acids shorter C. There would be no effect, as the intron would be removed successfully D. No protein would be produced, since mistakes are not tolerated E. A frameshift would occur, disrupting the protein downstream of the mutation

Explanation / Answer

When G at 5' splice site is mutated and GU of down stream is used for splicing The remaining sequence AAg, CGU are two amino acids added to polypeptideafter splicing during post trancriptional processing. Originally, the G at 5' splice site is not mutated and the remaining fragment is removed as intron. If the G is mutated and down stream GU is used as splice site, then the remaining fragment is two amino acid length exon and added to polypeptide. Therefore, option A is correct.

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