An IgG protein contains two copies of a large polypeptide (heavy chain) and two

Question

An IgG protein contains two copies of a large polypeptide (heavy chain) and two copies of a small polypeptide (light chain). structure contributes significantly to the tertiary structure of domains of both chains. Disulfide bonds link the heavy chains to one another and to the light chains. The chains are arranged in a Y-shaped structure where the two arms are linked to the base by a protease sensitive (“hinge”) region. a. Describe the chemical properties that determine how an antibody binds its target. How do these properties apply to the specificity of an antibody? (5 points) b. Which model of ligand binding best describes antibody binding? Justify your answer with specific examples with citations. (10 points)

Explanation / Answer

a) Antibodies are treated with protease like pepsin F(ab)2   Means that Fragment of antigen binding site and Fc ie., Fragment of crystallization

IgG protein contains two copies of a large polypeptide (heavy chain) and two copies of a small polypeptide (Light chain) structure contribute tertiary structure of domains of both chains. The chains are arranged in a Y-shaped structure where the two arms are linked to the base by a protease sensitive (hinge ) region.

b) Protein have a high specifity and only certain ligands can bind. High specifity can be explained by the complementary of the binding site and ligand (size , shape, charge or hydrophobic character)

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