The following is the DNA sequence of the entire protein-coding region for some s
ID: 227269 • Letter: T
Question
The following is the DNA sequence of the entire protein-coding region for some small gene in a eukaryote. Shown is the coding strand. The first row is the original sequence with no mutations. Subsequent rows represent a single mutation.
Mutation DNA Sequence
None 5’ ..A T G C T G A G C C G C G G C T G A.. 3’
A) 5’ ..A T G C T G A G A C G C G G C T G A.. 3’
B) 5’ ..A T G C T G A G C C G C G G T T G A.. 3’
C) 5’ ..A T G C T G G G C C G C G G C T G A.. 3’
The region without a mutation is transcribed, and then translated. Give the protein that is translated from this section of DNA. Use the single letter abbriviations for amino acids with no spaces.
N-___?__-C
Determine the molecular basis for each mutation and what effect there would be on the protein.
Mutation Molecular Basis Effect on Protein
A) transition or transversion nonsense, synonymous, nonsynonymous, readthrough
B) transition or transversion nonsense, synonymous, nonsynonymous, readthrough
C) transition or transversion nonsense, synonymous, nonsynonymous, readthrough
Explanation / Answer
A. Transversion, change of amino acid from serine to argenine, therefore nonsynonymous mutation.
B. Transition, synonymous (glycine)
C. Transition, nonsynonymous (ser to gly)
Protein sequence from the unmutated region:
MLSNG
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