Match the following (most appropriate combinations): rescues stalled eukaryotic

Question

Match the following (most appropriate combinations): rescues stalled eukaryotic ribosomes on mRNAs without stop codons RF1 Mimics the 3' end of aminoacylated tRNAs, but is not a tRNA RF2 Specific for UGA and UAA codons RF3 Needed for UAG, UGA and UAA codons puromycin Specific for UAG and UAA codons tmRNA Targets proteins to endoplasmic reticulum ski7 rescues stalled bacterial ribosomes on truncated mRNAs Exon junction complex (EJC) and Upf1/2 lead to degradation of eukaryotic mRNAs with premature N-terminal signal peptide sequence stop codons (PTC), also known as non-sense mediated decay (NMD)

Explanation / Answer

Answer:

1. Rescues stalled eukaryotic ribosomes on mRNAs without stop codons – ski7

2. Mimics the 3’ end of amino acylated tRNAs but is not a tRNA - Puromycin

3. Specific for UGA and UAA codons - RF2

4. Needed for UAG, UGA and UAA codons – RF3

5. Specific for UAG and UAA codons – RF1

6. Targets proteins to endoplasmic reticulum - N-terminal signal peptide sequence

7. Rescues stalled bacterial ribosomes on truncated mRNAs - tmRNA

8. Lead to degradation of eukaryotic mRNAs with premature stop codons (PTC), also known as non-sense mediated decay (NMD) - Exon junction complex (EJC) and Upf 1/2

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