You are investigating the interactions of integrin alpha and beta subunits and i

Question

You are investigating the interactions of integrin alpha and beta subunits and isolate the extracellular portion of an integrin as a soluble alpha/beta heterodimer. The heterodimer lacks the associated transmembrane and cytoplasmic domains normally present as part of the molecule. You experimentally link the alpha and beta subunits at the bases of their legs so that the ligand-binding regions of the alpha and beta subunits approach one another. Which of the following statements is true about the molecules formed?


The molecules are unable to bind a ligand.


The molecules denature their ligand.


The molecules are cleaved.


The molecules denature and degrade.


The molecules bind their ligand tightly.

Explanation / Answer

The molecules are unable to bind a ligand. The molecules are cleaved. The molecules denature and degrade.

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