DD is a 60 year old female, who weighs 102 lbs, is given a 300 mg loading dose o
ID: 238552 • Letter: D
Question
DD is a 60 year old female, who weighs 102 lbs, is given a 300 mg loading dose of an anticancer medication. At the same time, a continuous IV infusion is started at a rate of 13 mg/hr. The volume of distribution is 1 L/kg and the drug half-life is 12.1 hours. The physician wants drug levels drawn 28 hours after the loading dose was given and the infusion was started.
What is the expected plasma drug concentration when the patient's blood sample is collected 28 hours after the infusion began? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/L.
_________
Explanation / Answer
Loading dose of drug. = 300mg
Intravenous infusion rate. = 13mg /hr
Half life of drug. = 12.1 hr
Volume distribution. = 1L / kg
Weight of patient. = 102 lbs. = 46.26kg
Initial concentration Co. = D /Vd
= Dose. / volume distribution
Dose. = 300. + (13 28)
= 664mg /46.26 L
= 14.35mg/ L
Plasma concentration = Co. * e(-Ke * t)
= 14.35. *
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