QUESTION 4 A patient with atrial fibrillation is taking warfarin (Coumadin), whi

Question

QUESTION 4 A patient with atrial fibrillation is taking warfarin (Coumadin), which is significantly protein-bound. The patient develops sinusitis and is started on trimethoprim-sulfamethoxazole (Bactrim) to treat his infection. You are checking for drug interactions and learn that Bactrim has a stronger affinity for albumin than warfarin. What will happen to free warfarin levels in the blood once the antibiotic is started? a. Warfarin levels will increase. b. Warfarin levels will decrease. c. Warfarin levels will not change. d. Warfarin levels will be undetectable.

Explanation / Answer

The free warfarin levels in the blood once the antibiotic is started will; Warfarin levels will increase as now bactrim will compete with it for albumin less binding with albumin will make the Warfarin more free.

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