CE: Place the following events in HIV infection in order from 1 to 9. nds to the

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CE: Place the following events in HIV infection in order from 1 to 9. nds to the CD4 receptor and other surface markers on T helper cells (attachment) iral RNA is then reverse transcribed to DNA (this cDNA codes for RNA replication) ver time, the CD4-T cell counts drop and patient becomes at higher and higher risk for opportunistic nfections and cancers nfected cell becomes dysfunctional and is destroyed in this process HIV genes are then copled and transcribed along with the host DNA Ctranscript rotease enzymes cut polyproteins produced to produce viral protein tra tion & translation eins and viral RNA are assembled to form new HIV viruses Cassembly to be released from host cell IV envelope fuses to the CD4 cell membrane allowing the viral core and associated enzymes to enter the CD4 cell ("uncoating& internalization The enzyme integrase aids insertion and incorporation of the new cDNA controlling viral replication into the original host DNA. ("integration DED MATCHING: Place the letter of the sign or symptom from the bottom table on the line its major corresponding category of "AIDS Defining IlIness. Letter choices used only once. ay be more than one answer per line. CATEGORY SAMPLE CLINICAL FINDINGS Respiratory Infections rvous System Dysfunction GI System Dysfunction Cancers & Malignancies Wasting Syndrome L. HIV-Associated Neurocognitive ogystis jiroveci Pneumonia G. Karposi sarcoma lic & morphological yeast infection Disorders (HAND) H. Diarrhea I. Herpes simplex infection J. Mycobacterium tuberculosis M. Noninvasive anal carcihoma N. Mitcochondrial disorders O. Cytomegalovirus infe P. Non-Hodgkin lymphonm ssive Multifocal ha lopathy (PML) -- asive cervical carcinoma K. Lipid dystrophy sma gongii infection

Explanation / Answer

1. HIV binds to the CD4 receptor and other surface markers on T helper cells (attachemnt)

2. HIV envelope fuses to the CD4 cell membrane allowing the viral code and associated enzymes to enter the CD4 core (uncoating and internalization) (fusion)

3. Viral RNA is then reverse transcrribed to DNA (this cDNA codes for RNA replication)

4. The enzyme integrase aids insertion and incorporation of the new cDNA controlling viral replication of the original host DNA (integration)

5. HIV genes are then copied and transcribed along with the host DNA (tanscription &translation)

6. Protease enzmes cut polyprotiens produced to produce viral protein fragments (Cleavage)

7. Proteins and viral RNA are assembled to form new HIV viruses (Assembly) to be released from host cell.

8.Infected cells become dysfunctional and is destroyed in this process

9. Over time , the CD4-T cell counts drop and patient becomes at higher and higher risk for opportunistic infections and cancer

Respiratory infections: A, J,

Nervous system dysfunction: D, F, L

GI system Dysfunction: H, M

Cancers and malignancies: E, G, P

Wasting syndrome: K

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