A patient is taking an oral tyrosine kinase inhibitor for cancer treatment. He i

Question

A patient is taking an oral tyrosine kinase inhibitor for cancer treatment. He is also slightly depressed and is telling you about this herbal remedy, St. John’s Wort, he found on an internet forum. Which of the following is correct? 1.Anything from nature is good and harmless 2.St. John’s Wort can block metabolism of the cancer treatment and increase exposure, causing toxicity. 3.St. John’s Wort can increase metabolism of the cancer treatment and decrease exposure, causing loss of activity. 4.The patient could take his drug with grapefruit juice to counter the effect of the St. John’s Wort. 5.The patient should stop taking the tyrosine kinase inhibitor.

Explanation / Answer

it is risky to use St.Jhon's wort for patient taking tyrosine kinase inhibitor as it reduces the effectiveness of the drug by blocking the metabolism of cancer treatment and further cause toxicity.

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