Gmail4G 9:53 AM ? ? https://capscare.edubrite.com D Assignments, Chapter 16, Ant

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Gmail4G 9:53 AM ? ? https://capscare.edubrite.com D Assignments, Chapter 16, Anti-Inflammatory, Antiarthritis, and Related Agent Written Assignments 1. What are the therapeutic actions of salicylates and NSAIDs? 2. Some patients do not respond to traditional anti- inflammatory medications and try chrysotherapy (gold therapy). Summarize the use of gold therapy in the patient with rheumatic inflammatory conditions. Include common drugs used in gold therapy, therapeutic actions, indications, Ob reactions, and important d 3. Why is aspirin contraindicated in children with viral illnesses? If the child has a fever and cannot use aspirin, what antipyretic would be recommended? 4. Identify significant risk factors when a 75-year-old male is using Naprosyn for chronic back pain. Discuss nursing considerations that can be used to decrease risk factors interactions. Ob . Assign each group an anti-inflammatory drug classification (salicylates, NSAIDs, acetaminophen). Each prepares a presentation for the rest of the class. Presentation to include common drugs in anti-inflammatory group, therapeutic actions, indications, pharmacokinetics, contraindications, common adverse reactions, and important drug drug interactions. 2. Each group discusses and lists special considerations when using anti-inflammatory drugs in different age groups (children, adults, and older adults). Following the discussion of all age groups, decide which age group is at the highest risk when using anti-inflam

Explanation / Answer

1)ans) therapeutic actions of salicylate and NSAIDS:

Ot includes:have analgesic (pain blocking).due to prevention of PG mediated sensitisation of nerve endings.

Inhibit synthesis of prostaglandins.

Can block the inflammatory response.

Have a antipyretic properties(fever blocking).

Block two enzymes,known as COX-1 andCOX -2.

Anti platelet effect.

2)ans)chrysotherapy :or gold therapy:

action: absorbed by macrophages,which results in inhibition of phagocytosis.

Tissue destruction is decreased.

Pharmacokinetics:

Absorption varies based on its site of administration,widely distributed throughout the body and excreted in urine and feces.

Contraindications:

allergy,diabetes,CHF,renal or hepatic insufficiency,blood dyscrasias,pregnancy,lactation.

Adverse reactions:

Stomatitis,gingivitis,bone marrowdepression,dermatitis,interstitial pneumonia,anaphylactic shock.

Drug to drug interactions:

Penicillamine,antimalarias,cytotoxic drugs, or immunosuppressive agents.

3)ans) aspirin contraindicated in children : because aspirin ,also known as acetylsalicylic acid (ASA),is the most well known salicylate and responsible for salicylate poisoning.

Reye's syndrome usually occurs in children who have had a recently viral infection,such as chicken pox.usecof salicylate in children with viral infection may cause hepatic damage with fatty Infiltration.hence,aspirin contraindicated in children with viral infection.

Antipyretic use in children: Acetaminophen 10to15mg per kg,paracetmol,ibuprofen.

4)risk factors of Naproxen:heart disease,high blood pressure,history of bypass surgery,stroke,bleeding in intestine and stomach,death occurs older than 65years.

Nursing consideration: asess the client Condition.

Collect the previous history from client.

Explain the precautions before administration.

Group assignments:

1) classification of NSAIDS,acetaminophen:

it is classified into:A) nonselective COX inhibitors:

1) salicylate 2) ibuprofen 3) indomethacin 4) diclofenac 5)piroxicam6) mefenamic acid.

B)selective COX-2 inhibitors:celecoxib,meloxicam.

C) analgesic,antipyretic: paracetamol,metamizol,propiophenazone.

Side effects:nausea,vomiting,diarrhea,constipatio,decrease appetite,dizziness.

Indications: antipyretic,analgesic,antiinflammatory, bone injuries,cold or flu.

Action: both enzymes produce prostaglandins that promote inflammation,pain,fever.support platelet and protect the stomach.

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