Analyzing the Question Which hypnotic is most likely to be the safest option for

Question

Analyzing the Question Which hypnotic is most likely to be the safest option for a patient taking itraconazole (strong CYP 3A4 inhibitor)? Match the statements to the correct inquiry category below, assuming you have general knowledge and the information contained within the question: 1. The chemical and pharmacological natures of these medications 2. A hypnotic is a medication used to induce sleep 3. The definition of CYP3A4, and the relevance of it being inhibited 4. Do we have a system for systematic analysis of both what the drug does to the body and what the body does to the drug (i.e. can these be mutually exclusive parameters)? 5. Is there a common route by which drugs are removed from the body, and if so how specific or generalizable is it? 6. The objective of the question is to determine which drug is safest 7. The condition of safety is based on a patient taking itraconazole (a different kind of medication used for certairn infections) 8. The parameters of safety for these drugs -for example which side effects we should be concerned about 9. Itraconazole is a CYP 3A4 inhibitor 10. The options are all viable hypnotics (given information- again on an actual test you would not take this for granted) 11. The nature by which it affects the activity of medications in the body - although given the nature of the question, we assume it would somehow affect safety 12. How context-dependent are the parameters that must be considered to answer the question-for example would the answer vary based on demographics such as age? When you drag and drop your answers into the columns, put the lowest number for the column at the top. For instance if a column has 6,3, and 8 in it, 3 should be in the top drop spot, then 6 under it, then 8 in the bottom drop spot.

Explanation / Answer

What we know

3

6

8

9

11

What we know we dont know

1

2

4

12

What we dont know we dont know

5

7

10

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