QUESTION 7 Which of the following feature(s) of ASD can explain difficulties in

Question

QUESTION 7

Which of the following feature(s) of ASD can explain difficulties in sensory information integration and processing?

             Reduced pruning resulting in excessive short-range connectivity and lack of synaptic refinement

Reduced cerebellar size as the cerebellum processes sensory information

The high concordance of ASD incidence among identical twins

A and B

QUESTION 8

Which of the following is false regarding schizophrenia?

Individuals with this disease have a reduced prefrontal cortex

Pathology results from impaired pruning of dopamingergic neurons, which results in episodes of psychosis

Genetic mutations that predispose individuals to disease can relate to neuronal pruning

Reelin deficits can result in cortical abnormalities

QUESTION 9

Which of the following proteins are associated with ABeta protein clearance mechanisms?

ApoE4

Presenilin

APP

B and C

Explanation / Answer

Q9 ans: B and C ,presenilin& APP

Presenilin-1 (ps-1) is a presenilin protein that in humans is encoded by the psen-1 gene.presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in gereration of amyloid beta from amyloid precursor protein (APP)

Q8 ans: genetic mutations that predispose individuals to disease can relate to neuronal pruning

Q7 ans: A&B Reduce cerebellar size as the cerebellum processes sensory information, Reduced pruning resulting in excessive short range connectivity and lack of synaptic refinement

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