amyloid fibrils are 8. Amyloid fibrils are associated with many fatal degenerati
ID: 253066 • Letter: A
Question
amyloid fibrils are 8. Amyloid fibrils are associated with many fatal degenerative disease of humans and livestock. Livestock diseases such as scrapie in sheep and bovine spongiform encephalitis (BSE, or mad cow disease) have major negative impacts on agriculture. Human diseases characterized by amyloid fibrils include Alzheimer's disease and Creutzfeldt-Jakob disease. The images below show a short segment of a typical amyloid fibril. The image on the left shows the side chains protruding from the faces of the beta sheets. Chose all the true statements about amyloid fibrils. A. Proteins that convert to an amyloid fibril structure tend to have a low solubility in their native form. B. Soluble proteins that misfold and form amyloid fibrils become insoluble C. An amyloid fibril typically forms from aggregates ef-misfolded-peptides resulting from frameshift-mutations. D, Nucleation of amyloid structure may be triggered when two beta-sheet regions from two partially folded proteins associate.Explanation / Answer
Following are the true statements about amyloid fibrils:
B. soluble proteins that misfold and become amyloid fibrils become insoluble.
C. An amyloid fibril typically forms from aggregates of misfolded peptides resulting from frameshift mutation.
D. Nucleation of amyloid structure may be triggered when two beta sheet regions from two partially folded proteins associate.
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