32. During infection, Salmonella Typhimurium can express flagella to move throug

Question

32. During infection, Salmonella Typhimurium can express flagella to move through the intestines infect host cells, and evade the host immune system. Flagella are multi-protein structures expressed from a coordinated set of genes regulated as a single unit. While important, flagella are not expressed all the time and depend on a specific signal to be expressed Please discuss the details of this gene arrangement, protein expression, and provide another example of a similar gene expression mechanism. Use the figure below as needed. (10 points) B C D EG H ?> Example layout of genes involved in making flagella in Salmonella

Explanation / Answer

Flagella, a locomotor organ has sequences of genes for the normal mobility of the organism, as the disturbance in genes causes loss of motility. The structural genes in the flagella was arranged as early, middle and late and the promotors are also arranged in three classes called class 1, 2 and 3. In operons, some of the genes which gets transcribed from flagella promotors are flhE, fliY, fliZ and fliT and these genes have little effect on motility and genes responsible for transcription of other flagella genes are fliT and fliZ. flhDC Operon is expressed from class 1promotor. flhD and flhC proteins from heteromultimeric complex acts as transcription activator, which is present in class 2promotor. fliA genes encode flagella specific transcription factor, which is present in class 3 promotors.

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