Q.) Below is a family pedigree where autozygosity mapping was used to identify t

Question

Q.) Below is a family pedigree where autozygosity mapping was used to identify the region of chromosome 15 that contains the gene responsible for a recessive trait. Based on the known marker genotypes, identify the minimal region that must contain the disease-causing gene. Place a box around the minimal region and then justify your answer. (5)

5115362526 5115362376 7 6 5115362526 6115362526 5115362376 9 5115362526 5115362376 6323222672 5115362376 5115362376 5235232261 2215362376 5115362526 7 5115362376 5115362526 5115362376 5115362526 5115362526 5115362526 6 5115362526 5242362526 7223452375 5115362526 7157231682 7223452375 5242362526 7157231682 5242362526 7157231682 8 7157231682 5231462526 5115362376 5231462526 4267142395 5231462526 5115362376 5231462526 6122354452 6122354452 4215362376 5115362376 4267142395 5115362376 5231462526 5115362376 5231462526 4215362376

Explanation / Answer

The minimal region for disease causing is from M6 to M7 because it is the minimal shared region within all affected individuals.

Male 3 is identical by state because it has inherited markers from different ancestral allele while Male 20 is identical by decent because it inherited markers from same ancestral allele.

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