HER2 is a receptor tyrosine kinase that is overexpressed in a subset of breast c

Question

HER2 is a receptor tyrosine kinase that is overexpressed in a subset of breast cancers. HER2+ breast cancers are typically treated with Trastuzumab, a HER2 antibody that inhibits HER2 activity. However many patients eventually develop resistance to Trastuzumab, indicating that some tumor cells acquire mutations that bypass HER2 signaling. Based on what you know about RTK signaling, propose a specific gene mutation that could allow a HER2+ cell to promote its own proliferation independently of HER2 and resist Trastuzumab. Explain.

Explanation / Answer

Ans- the specific gene mutation in HER2 gene include missense mutation in which one or more base pair of the gene is substituted, this substitution change the whole sense of the gene and the resultant protein will be mutated. This protein will not be specific for production of signals which were required to act as receptor.

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