Let\'s make a chimeric GPCR. You take the N-terminal extracellular domain, the f

Question

Let's make a chimeric GPCR. You take the N-terminal extracellular domain, the first 4 transmembrane domains and cytosolic loops C1 and C2 from the ?AR and fuse it to the last 3 transmembrane domains, the cytosolic C3 loop and C-terminal domain of the acetylcholine receptor. You express this chimeric receptor in otherwise normal liver cells that lack both wild-type (normal) ?-adrenergic and acetylcholine receptors. Which of the following would accurately describe changes in the activities of PKA and GPK in response to the addition of epinephrine to these cells?

A. Both PKA and GPK are activated 100%
B. Both PKA and GPK remain inactive
C. PKA remains inactive. GPK is activated 50% because it binds to Ca2+•Calmodulin
D. PKA is activated 100%. GPK is activated 50% because it is phosphorylated, but does not bind to Ca2+•Calmodulin
E. PKA is activated 100%. GPK remains inactivate

Explanation / Answer

c. PKA remains inactive. GPK is activated 50% because it binds to Ca2+•Calmodulin

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