8. For the attachment of the translational complexes to the ER membrane, the ER

Question

8. For the attachment of the translational complexes to the ER membrane, the ER signal sequence must be recognized by soluble 9. A protein that is imported into the ER will remain in the ER if it has a(n) 10. A protein that has no sorting signal will end up in the 11. A single-pass transmembrane protein with an N-terminal ER signal sequence also has an internal particles signal. 12. A single-pass transmembrane protein without an N-terminal ER signal sequence has an internal 13. Multi-pass transmembrane proteins have internal and sequences 14. The two mechanisms that prevent the accumulation of unfolded proteins in the ER are and 15. Proteins synthesized on freeribosomes are initaly relesed in thele 16. The transit sequences of Mitochondrial proteins are removed by the 17. Proteins destined to the lysosome are labeled with 18. In the ER, protein folding is often accompanied by formation of 19. A protein destined to the nucleoplasm should have a 20. The transit signal of a mitochondrial protein is located at the 21. A non-Giolgi protein that reaches the TGN and has neither a lysosomal tag, nor an ER retention signal bonds. signal. terminus of the polypeptide will probably be pathway 22. The TGN is the sorting center for the

Explanation / Answer

10. Cytosol

11. Stop transfer signal

15. Cytosol

16. Matrix signal peptidases

17. Sugar with phosphate group/Mannose-6-phosphate label

18. Disulfide bonds

22. Secretory pathway

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