Use the mutations interactive to determine which of the following are silent mut

Question

Use the mutations interactive to determine which of the following are silent mutations. The adenine of the start codon is position +1 a substitution of a U nucleotide at position +9 in the antisense strand a transversion of A in the histidine codon of the antisense strand a subsitution from G to T in the arginine codon of the antisense stand an A nucleotide is inserted at position +2 in the sense strand a transversion at position +12 in the antisense strand a single nucleotide deletion at position +12 in the antisense strand ? ? ?Previous 3 Give Up & View Solution (C) Check Answer Next E Hint Silent mutations ultimately do not affect the expressed gene product.

Explanation / Answer

Correct: a substitution of a U nucleotide at the position +9 in the antisense strand and a traverse at the position +12 in the antisense strand will not cause any difference in the original amino acid sequence because this is a nonsynonymous substitution.

Hence, the correct options are (1) and (5).

Incorrect: all the other options will lead to some deleterious changes in the nucleotide sequence that will ultimately lead to cause the change in amino acid.

Hence, the options (2), (3), (4) and (6) are incorrect.

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