Is there a deficiency in the cellular branch of the patient\'s adaptive immune s

Question

Is there a deficiency in the cellular branch of the patient's adaptive immune system? Explain.

A 5-year-old girl was admitted to the hospital with a tender mass in the right upper quadrant of her abdomen, along with severe dyspnea, a persistent cough, and chest and abdominal pain She had a history of several bouts of pneumonia, starting at momths Chest X-ravs showed cloudy spots consistent with a lung infection. Sonography rerealed a liver abscess. The abscess was drained and a sample was cultured and examined by microscopy (seephoto). Note: the photo may look fuzzy when printed; be sure to look at the online version ] Blood tests revealed a white blood cell cmmt nf 12.1 × 109L (nonnal is 4-11 × 10,L). The ratio of neutrophils to lymphocytes was approximately 3:2 The serum IgG level was 16.5 mgmL, IgM was 2.5 mgmL, and IgA was 1.75 mgmL A sample of the patient's white blood cells was mixed with the fluorescent cye diavdrorhadamine (DHR) and with PNMA, asubstance that nonspecifically stimulates neutrophils (mimicking the response that occurs when a neutrophil encounters a pathogen). IfH.O, is produced in response to stimulation, DHR fluorescence increases. The white blood cells were analyzed before (Testing) and after the PMA stimulation Cell counts (number of cells) is plotted against DHR Auorescence for mhite blood cells obtained from a normal cantrol and from the patient Resting Stimulated with PMA Normal control 10 DHR 123 [Resting) DHR 123 (4) Patient HR 123 (Restingl

Explanation / Answer

Yes. There is a deficiency in the cellular branch of the pateint's adaptive immune system.

Flow cytometry study shows that when normal patient stimulated with PMA, the number of cells with DHR fluoroscence is higher compared to the patient's number of cells. That means there is lesser white blood cells are getting activated in patient's body compared to normal person.

It indicates that there is deficiency in the cellular branch of the patient's adaptive immune system.

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