There is one nucleosome for every 200 bp of eukaryotic DNA. Nucleosomes can be a

ID: 255915 • Letter: T

Question

There is one nucleosome for every 200 bp of eukaryotic DNA. Nucleosomes can be approximated as disks 11.0 nm in diameter, and 6.00 nm long.

A chicken haploid cell consists of 39 chromosomes and 1.2×109 bp. How many nucleosomes are in a chicken haploid cell?

The number of nucleosomes = 6,000,000 nucleosomes.

If all the DNA molecules in the cell are in the B-conformation, what is the sum of their lengths in meters?

(In B-DNA, the base pair rungs are 0.34 nm apart.)

The length of B-DNA, 1.2×109 base pairs long = _____________m

A chicken haploid cell consists of 39 chromosomes and 1.2×109 bp. How many nucleosomes are in a chicken haploid cell?

The number of nucleosomes = 6,000,000 nucleosomes.

Ans. #1. Given, size of human genome= 1.2 x 109 bp

There is 1 nucleosome per 200 bp

Or, 1 bp is equivalent to 1/200 nucleosome

# Now, no. of nucleosome = Genome size x (frequency of nucleosome occurrence)

= (1.2 x 109 bp) x (1 nucleosome / 200 bp)

= 6.0 x 106 nucleosomes

#2. Given, length per bp = 0.34 nm / bp

Genome size = 1.2 x 109 bp

# Total length of genome = Genome size x (length per bp)

= (1.2 x 109 bp) x (0.34 nm/ bp)

= 4.08 x 108 nm

= 0.408 m

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