2. A new metabolic pathway (35 points). A new metabolic pathway has been partial
ID: 256430 • Letter: 2
Question
2. A new metabolic pathway (35 points). A new metabolic pathway has been partially characterized. Known features of the pathway are shown below. Some details, including the chemical structures of intermediates, remain unknown: reaction 1 reaction 2 reaction 3 reaction 4 reaction 5 CO2 ATP ADP NADPH NADP Glyceraldehyde H2O H2O 3-phosphate AG 0.5 kJ/mol a. Is this pathway likely to be anabolic or catabolic? Provide two pieces of evidence b. Which step of this pathway do you predict will be most highly regulated? Why (1- C. What would the equilibrium constant be for the net reaction of the entire that support your answer. 3 sentences)? combined pathway from A to F, at 37°C? Show your work for the calculation d. One reaction in this pathway is likely to use a "bypass reaction" using a different enzyme if the pathway is run in reverse i. Which reaction is this? Why (1 sentence)? ii. Propose a balanced chemical equation for this "bypass reaction."Explanation / Answer
A)The given new metabolic pathway is an anabolic reaction(energy untiltizing pathway).In anabolic reaction the energy is transfred from ATP to complex molecules which is taking place in the reaction step 2.Such reaction takes place in the metabolism of protein,lipid and starch.
Anabolic pathway consume ATP,NADPH and FADH2
B)The reaction 2 is the highly regulating step of the pathway.As the negative delta G is higher than other reaction steps.As this step take part in the storage of energy in the form of ADP for futhure metbolism.
c)The rate of forward rection =rate of backward reaction
The equilibrium constant of backward reaction is reciprocal to equilibrium constant of forward reaction.
K=1/K'
D)The conversion of B to D bypassing C .Bypass reaction are usualy hydrolysis reaction.
E)4ATP+2NADPH-------->4 ADP+2NAD+ +6iP
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