R UNDERS inin your own words why one of the daughter strands forms in fragments
ID: 256586 • Letter: R
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R UNDERS inin your own words why one of the daughter strands forms in fragments instead o continuous strand? Can your group in fragments instead of a long come up with an analogy? 2. A new form of DNA is discovered that appears to be able to replicate itself both in the 3' to 5" and 5 to s direction. How would this newly discovered DNA replication differ from replication as w know it? Given the mechanism of replication, is it surprising that the covalent bonds that hold the DNA backbone together a relatively strong compared to the hydrogen bonds that hold the two strands together? Why/why not? 3. It turns out that the rumors about Roswell, NM are true and the US government has samples of alien tissue as a result of the UFO crash landing. You are asked to determine if these aliens use nucleic acids, protein, or some other compound as hereditary material. What kinds of experiments could you propose to make this determination? 4.Explanation / Answer
1. All the existing DNA polymerases can extend an existing strand only in 5'-3' direction. It can not extend in 3'-5' direction. DNA polymerase can not even initiate DNA synthesis. It requires an existing primer for strand new synthesis. Hence DNA replication at the replication fork is discontinuous. The leading strand is synthesized continuously while the lagging strand is synthesized in fragments.
Analogy: A two-way road paving. We can pave the way using two machines that move in the same direction. But one will pave in one continuous stretch while the other in discontinuous stretches in opposite direction.
2. If a new organism contains a DNA polymerase that can extend the DNA strand in both 3'5' and 5'-3' direction, the synthesis of new daughter strands at the replication fork would be continuous.
3. No. H-bonds are weaker than a covalent bond. H-bonds are to be broken often for many physiological processes such as transcription and replication which involve strand separation. The breaking phosphodiester bonds is a rare phenomenon occurs only during strand invasion, crossover etc..
4. Isolate different fractions of biomolecules and transform them into a suitable host.
Proteins+carbohydrate+nucleic acids+ lipids = Different types of biomolecules.
Treat the sample with protease, nuclease, lipase, and glycosidases in each experiment separately and observe which factor can cause transformation in the suitable host.
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