SOLVING PROBLEMS 1. A research group is studying a bacterium X that binds to muc

Question

SOLVING PROBLEMS 1. A research group is studying a bacterium X that binds to mucosal cells in the lung and invades. Wild type X has an LDso value of 10 bacteria when admin istered to mice by inhalation. Using transposon mu- tagenesis, the researchers have isolated two mutants of X that they call Xmut1 and Xmut2, both of which have LDso values of 10% when inhaled by mice. How- ever, in tissue culture cells, Xmutl can invade the cells just as well as wild-type X, while Xmut2 cannot. Pro- vide a possible explanation for these results.

Explanation / Answer

Mutation is permanent alteration in nucleotide sequence of an genome.

Here Xmut1 and Xmut2both have ld50 values of 10^5when inhaled by mice it shows ld50 value but in tissue culture Xmut2 fails to expresss itself due conservative missence mutation as here the structure remains same but the phenotype is changed.Xmut1 must be silent mutations where there had been very small change which did not change rhe phenotype at all

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