Use the mutations interactive to determine which of the following are silent mut

Question

Use the mutations interactive to determine which of the following are silent mutations. The adenine of the start codon is position +1 a single nucleotide deletion at position +12 in the antisense strand a transversion at position +12 in the antisense strand a subsitution from G to T in the arginine codon of the antisense stand an A nucleotide is inserted at position +2 n the sense strand substitution of a U nucleotide at position +9 in the antisense strand transversion of A in the histidine codon of the antisense strand a

Explanation / Answer

Silent Mutation

When the base substitution in the DNA , there is no change in the amino acid synthesized during translation.

for example- CUA is code for Leu, if its A is replaced by C then it will be CUC, which is also Leu.

Answer.

# Nucleotide deletion will result into the Frame shift Mutation.

# Transversion at +12 position will not change the amino acid Thr, so it is silent mutation.

# Arginine will change.

# Insertion of Nucleotide will change the frame. it will no more silent mutation.

# Trptophan will convert into cystein on substituting U at +9 position.

# Histidine will change into another amino acid.

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