1. (1pt each) The following diagram lists different classes of mutants found in
ID: 257157 • Letter: 1
Question
1. (1pt each) The following diagram lists different classes of mutants found in a temperature sensitive screen for defective secretion. Red dots represent proteins that are normally secreted but accumulate in different organelles when proteins in that class are mutated. Each of these classes includes many mutant proteins that function at similar steps in the secretory pathway to cause accumulation in the same organelle. Class A Class B Class c Class D Class E ER Golgi Fate of Normal secreted secretion proteins in secretory inER-to-Golgi, transport vesicles inthe cytosol ?n Golgi Transport secretor)y inrough ER vesicles Transport from to cell surface Defoctive function Fusion of Transport into the ER Budding of vesicles from transport vesicles from Golgi to secretory vesicles the rough ER with Golgi vesicles Please circle which class the following mutant proteins would belong to. Mutant pr A signal recognition particle unable to pause translation A v-SNARE on the plasma membrane unable to bind t-SNAREs A receptor in the trans-Golgi unable to bind to adapters COPII coat proteins aren't recruited by Sar1-GTP A t-SNARE on COPII coated vesicles unable to bind v-SNAREs A B CDE A BCDE A B C DE A BC DE A BC DEExplanation / Answer
Answer.1] A signal recognition particle unable to pause translation = class B. because in this protien get accumulate in ER as signal recognition protein help in transporting of secretory and membrane proteins to the plasma membrane
2] A v-SNARE on the plasma membrane unable to bind to t-SNAREs = class E as v-SNARE and t-SNARE help in fusion of vesicle to membrane.
3] A receptor in the trans Golgi unable to bind to adapters = Class D, trans golgi makes the vesicle if it defects then there is accumulation in Golgi.
4] COPII coat protien are not recruited by Sar1-GTP = class C, COPII uses in cargo of protein from ER to Golgi.
5] t-SNARE on COPII coated vesicle unable to bind to v-SNAREs = class A because COPII froms vesicle that fuses with ER.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.