please show as simply as possible how the answers are obtained. Dilated cardiomy

Question

please show as simply as possible how the answers are obtained.

Dilated cardiomyopathy (DCM) in dogs occurs because of abnormal enlargement of the chambers of the heart with simultaneous reduction in cardiac output. The left ventricle is always involved, but in advanced cases, dilation of all four chambers might be involved. Genetically, dogs inherit DCM as an autosomal dominant disorder. However, dogs heterozygous for the DCM allele do not always express the disorder. a. Provide the terminology that best describes why this disorder may not be expressed in all dogs that are heterozygous for the DCM allele. b. In some dogs, when the DCM allele is present, DCM may manifest as a mild disorder, whereas, in some other dogs DCM may appear quite severe. What terminology might you use to describe this type of gene expression pattern? In guinea pigs, coat color can be white, cream or yellow. Of these three phenotypes, only the cream-colored guinea pigs never breed true. When two cream-colored guinea pigs are white. A cream-colored guinea pig by are crossed, s are yellow, % are cream and 4 white guinea cross yields cream and ii white offspring. Ccem a. How many genes control coat color in the guinea pig? b. Give the mode of inheritance of coat color in the guinea pig c. Why is it impossible for cream-colored guinea pigs to breed true? 10. In Humans, Hemochromatosis (excessive iron in the blood) is a dominant disorder showing 33 % penetrance. A person who is heterozygous for Hemochromatosis mates with a person who is also heterozygous for hemochromatosis. Hint: Do not disregard any information given in the scenario above. What is the probability that the couple will have 2 children with Hemochromatosis? What is the probability that the couple will have a child with Hemochromatosis or a child without hemochromatosis? a. b.

Explanation / Answer

9a) Two genes are maitaining the coat colour in guineapig, C and c

b) mode of inheritance is autosomal

c)as cream.olour is obtained by cross of white and yellow colour, which has the genotype of Cc. This is a heterozygous for C and c.

Cc X Cc

C

c

C

CC

yellow

Cc

cream

c

Cc                          

cream

cc

white

Cc X cc

C

c

c

Cc

cream

Cc

white

c

Cc

cream

Cc

white

C

c

C

CC

yellow

Cc

cream

c

Cc                          

cream

cc

white

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