Which of the following statements is correct about antigen presentation by class

Question

Which of the following statements is correct about antigen presentation by class I and class Il MHC molecules? Multiple Choice Class I MHC molecules bind to fragments that initially come from antigens outside the cell, thus they undergo exogenous antigen processing. An antigen-presenting cell (APC), such as a macrophage, dendritic cell, or B cell, takes in the MHC molecule by receptor-mediated endocytosis or phagocytosis and produces MHC fragments by digestion in the phagolysosome. The class IMHC molecule is presented on the surface together with its endogenous antigen, enabling the host cell to present the antigen to a subset of T cells known as cytotoxic T lymphocytes. Class II MHC molecules bind to fragments that initially come from antigens outside the cell, thus they undergo endogenous antigen processing

Explanation / Answer

Answer:

Class II MHC molecules bind to fragments that initially come from antigens outside the cell, thus they undergo endogenous antigen processing.

Explanation:

MHC class I molecules present degradation products derived from intracellular (endogenous) proteins in the cytosol. MHC class II molecules present fragments derived from extracellular (exogenous) proteins that are located in an intracellular compartment.

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