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6. (10 encodes the fi pts) Given the wild type (wt) DNA sequence below (non-temp

ID: 257405 • Letter: 6

Question

6. (10 encodes the fi pts) Given the wild type (wt) DNA sequence below (non-template strand shown), which rst 5 codons of a gene, match the mutants with the appropriate classifications by cing the letter(s) thea careful to comp missing/addareach mutant back to the wt sequence, Changed bases are underlined, esenting the appropriate term(s) next to it. Be thorough, and be missing/additional bases should be obvious. Use the provided codon table. wt: ATG CAG TAC TTT mut1: ATG CAG TCT TT? mut2: ATG IAG TAC TTT mut3: ATG CAG TCC TTT mut4: ATG CCC CAG TAC TTT A. Insertion B. Deletion C. Silent D. Frameshift E. Missense F. Nonsense 7. Below are two homologous chromosomes with genes labeled in letters, and repetitive regions are labeled with R+number (R1, R2 etc...). a) (5pts) A crossover between which two repetitive regions will give one chromosome where genes C and D are deleted, and another where C and D are duplicated? b) (5pts) Why are triploid organisms usually sterile? A. Three copies of each gene will cause too much gene expression B. The vast majority of meiotic poducts will be aneuploid C. Meiosis is impossible with more than two homologous chromosome copies D. Many gametes will be missing one or more chromosomes

Explanation / Answer

6.
1. Deletion
2. Nonsense
3. Missense
4. Insertion

7. Between R1 and R3

b. Meiosis is impossible with more than two homologous chromosome copies.

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