3) Werners syndrome, a recessive disorder characterized by progressive accelerat

Question

3) Werners syndrome, a recessive disorder characterized by progressive accelerated aging. In a particular population n, the frequency of Werner's syndrome among newborns is 1 in 20,000 (i.e. 0.00005). Assuming random mating, what was the frequency of alleles for Werners syndrome in reproductive adults of the previous generation? 3b) Knowing that the inbreeding coefficient for progeny amongst first cousins is 1/16, calculate the frequency of children of children born with Werner syndrome if there is mating between first cousins.

Explanation / Answer

Answer 3(a)

Allele frequency can be calculated by Hardy weinberg equation:

p + q = 1 , Werners syndrome is autosomal recessive

q2 = .00005, q = .00707

frequency of recessive alle in population is 0.00707 or .707%.

3(b) .00390625

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