2)Based on the gene, mRNA and protein sequences that follow, what type of mutati

Question

2)Based on the gene, mRNA and protein sequences that follow, what type of mutation-polypeptide effect has occurred? Normal gene: TAC GCC GGC CCG AAA TTT ACT mRNA: AUG CGG CCG GGC UUU AAA UGA Normal protein: Methionine-Arginine-Proline-Glycine-Phenylalanine-Lysine Mutated gene: TAC GCC GGT CCG AAA TTT ACT mRNA: AUG CGG CCA GGC UUU AAA UGA Protein: Methionine-Arginine-Proline-Glycine-Phenylanine-Lysine a)deletion: silent or no change b)substitution: change in one amino acid c)substitution: silent or no change

Explanation / Answer

TAC GCC GGC CCG AAA TTT ACT:DNA normal
TAC GCC GGT CCG AAA TTTDNA mutated

AUG CGG CCG GGC UUU AAA UGA: RNA normal
AUG CGG CCA GGC UUU AAA UGA: RNA mutated

Methionine-Arginine-Proline-Glycine-Phenylalanine-Lysine: Protein normal
Methionine-Arginine-Proline-Glycine-Phenylalanine-Lysine: Protein mutated

The answer is c)substitution: silent or no change

Because the subsitution or change at 9th nucleotide leads to the same amino acid i.e proline, hence it is silent mutation.

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