Which statement is TRUE? A variable gene segment is a long DNA fragment within t
ID: 257655 • Letter: W
Question
Which statement is TRUE?
A variable gene segment is a long DNA fragment within the genomic immunoglobulin gene.
Five variable gene segments are present in the genomic DNA of a developing B cell.
A V exon is formed during somatic recombination and is composed of two or three gene segments, one of which is a variable gene segment.
All these statements are true.
Answers: A.A variable gene segment is a long DNA fragment within the genomic immunoglobulin gene.
B.Five variable gene segments are present in the genomic DNA of a developing B cell.
C.A V exon is formed during somatic recombination and is composed of two or three gene segments, one of which is a variable gene segment.
D.All these statements are true.
Explanation / Answer
D. all of these.
Notably, variable gene posses significant sequence variations from one immunoglobulin to other of the same class.There are five variable gene segment at the locus present in the genomic DNA of a developing B cell. Through somatic recombination or DNA rearrangement and/or deletion these variation are found in the V gene encoded protein. Therefore, the exon are found through somatic recombination and they are composed of two or three gene segments, one of which is a variable gene segment. Thus, during B-cell division, the chromosomes of their progeny cells bear the selected allelic genes.
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