During NHEJ (Non Homologous End Joining) random numbers of nucleotides can be in

Question

During NHEJ (Non Homologous End Joining) random numbers of nucleotides can be inserted or deleted. If insertion or deletion (InDel) mutations are not a multiple of three nucleotides, ______ mutations will result in the coding region of a gene. These types of InDel mutations will most likely produce B-cells that _______________________ due to the presence of premature stop codons.

point / do not make functional antibodies

point / make functional antibodies

frame shift/ do not make functional antibodies

frame shift/ make functional antibodies

point / do not make functional antibodies

point / make functional antibodies

frame shift/ do not make functional antibodies

frame shift/ make functional antibodies

Explanation / Answer

Answer is that if the insertion or deletion are not in. A multiple of three this will change the reason frame of gene leading to frameshift mutation. Due to premature stop codons B cells will not be able to make functional antibodies.So the third option is the correct answer.

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