(5) Which of the following statements about Vitamin K, EF-hand domains and GLA d
ID: 257980 • Letter: #
Question
(5) Which of the following statements about Vitamin K, EF-hand domains and GLA domains are true (indicate all that are true, 5 points) (A) Vitamin K is necessary for the -carboxylation of glutamic acid residues in EF-hand domains (B) Vitamin K is necessary for the 0-carboxylation of glutamic acid residues in GLA domains (C) Vitamin K is an eicosanoid whose binding to a G- protein linked receptor leads to Ca2 release in the cytoplasm, which calcium binds proteins with GLA domains (D) Vitamin K is a steroid whose binding to nuclear to an increase in transcription of calcium receptors leads binding proteins (E) The ability of Vitamin K to react with molecular oxygen, generating a strong base as an intermediate, is crucial to its activity (6) rite the molecule or class of molecules described by cach clue. If the clue describes more than one (type of) molecule, give an example of a molecule or class of molecules described by the clue (I point each) (A) Molecule that "stores" genetic information, i.e. the molecule that genes are made of (B) A non-reducing sugar (provide one example of a compound in this category) (C) Nucleic acid base (nucleobase) present in DNA instead of uracil due to uracil's tendency to tautomerize (D) An amino acid residue likely to be found at the edge of spanning helix as well as to be involved in a membrane binding with galactose residues in oligosaccharidesExplanation / Answer
(5) A)- True - vitamin K carboxylates many vitamin k dependent proteins, to make them active for various processes like calcium binding and homeostasis, apoptosis, hemostasis, growth control and more.
B) True - vitamin K carboxylates many vitamin k dependent proteins like GLA, to make them active for various processes like calcium binding and homeostasis, apoptosis, hemostasis, growth control and more. GLA when activated acts to inhibit calcium deposition in blood vessels.
C)FALSE - vitamin K is not an eicasinoid, and its binding does the reverse i.e binds calcium ions via calcium binding proteins.
D)FALSE - vitamin k is not a steriod
E) TRUE - Vitamin K acts as a hydrogen scavenger, upon reacting with oxygen,and is a crucial step in blood clotting pathway.
6)
A) DNA or deoxyribonucleic acids store genetic information.
B)Sucrose ,Trehalose
C) Thymine
D) These amino acids could help in galactose transport across the membrane, Example Tyrosine ,Tryptophan, Phenylalanine (aromatic amino acids) or Asparagine
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