5) State whether the statement below is true or false and explain why. In most a

Question

5) State whether the statement below is true or false and explain why. In most animal cells minus-end directed cargo transport along actin requires only 1 motor protein, while plus-end directed cargo transport along actin requires more than 1 protein. 7) a) Four major drugs routinely used to study the cytoskeletal network are Cytochalasin B, Phallodin, Nocodazole, and Colchicine. Discuss 1) the effect each drug has on the cytoskeleton, 2) the mechanism by which each drug effects the cytoskeleton, and 3) the cytoskeletal protein each drug acts upon. (4 pts) b) Which of the drugs mentioned above are toxic to cells? Explain your reasoning (2pts)

Explanation / Answer

1. The minus ends grow rapidly than the plus ends of actin filaments. This differences is growth rate reflected in adifference in the cell concentration for addtion of monomers to the two ends of the filaments.

2. Drug name: Target site Effect

Cytochalasin B Actin filament Prevents polymerization

Phallodin Actin filament Stabilize the filaments

Nocodazole Microtubule Stabilize the microtubules therefore prevents mitosis

Colchicine Microtubule Prevent polymeriztion

3. Some cytoskeletal drugs stabilize a component of the cytoskeleton. Such taxol with stabilize microtubules or Phalloidin which stabilize actin filaments

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