Evolutions question: Albinism is due to a recessive, autosomal mutation. The fre

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Evolutions question: Albinism is due to a recessive, autosomal mutation. The frequency of albino squirrels is 4x10^-6 while heterozygous squirrels, which are tan colored (and are lighter than wild type squirrels) occur at frequency 0.004 assume the population in a mutation selection balance. a) what is the frequency of the albino allele? Show work b) if the mutation rate to new albino alleles is 10^-6 what is the reduction of fitness of the heterozygote? Evolutions question: Albinism is due to a recessive, autosomal mutation. The frequency of albino squirrels is 4x10^-6 while heterozygous squirrels, which are tan colored (and are lighter than wild type squirrels) occur at frequency 0.004 assume the population in a mutation selection balance. a) what is the frequency of the albino allele? Show work b) if the mutation rate to new albino alleles is 10^-6 what is the reduction of fitness of the heterozygote? a) what is the frequency of the albino allele? Show work b) if the mutation rate to new albino alleles is 10^-6 what is the reduction of fitness of the heterozygote?

Explanation / Answer

a) Let frequency of wild type be=p, frequency of albino=q

p+q=1 (based on mutation selection balance)

for 2 allele frquency, q2=4*10-6

single allele frequency for albino q=2*10-3

b)For frequency of 4*10-6, the tan colored (heterozygote) frequency is 0.004. For 10-6 as a new mutation rate the tan colored will be 0.001. Thus the reduction is 4 fold in terms of fitness.

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