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Huntington disease displays anticipation. This means we can anticipate: that the

ID: 259194 • Letter: H

Question

Huntington disease displays anticipation. This means we can anticipate:

that the disease will not appear in some family members

that the disease will skip a certain generation

that the disease will have a lower age of onset in individuals of more recent generations

that the disease will be more severely expressed in homozygous individuals

John with blood type AB+ and Mary with blood type O+ have three children with blood types A+, B- and O-. What are the genotypes of John and Mary?

John is HHABDd and Mary is hhBODd

John is hhABDd and Mary is HhOOdd

John is HhABDd and Mary is HHOODd

John is HhABDd and Mary is HhOODd

A.

that the disease will not appear in some family members

B.

that the disease will skip a certain generation

C.

that the disease will have a lower age of onset in individuals of more recent generations

D.

that the disease will be more severely expressed in homozygous individuals

Explanation / Answer

Answer:

1). D. that the disease will be more severely expressed in homozygous individuals

Explanation:

Anticipation is most often seen with certain genetic disorders of the nervous system, such as Huntington disease, myotonic dystrophy, and fragile X syndrome.

2). D. John is HhABDd and Mary is HhOODd

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