Which of the following is not a co-factor or substrate required for fatty acid b

Question

Which of the following is not a co-factor or substrate required for fatty acid biosynthesis? Select one: O a. Malonyl-CoA O b. NADH O c. NADPH O d. Acetyl-CoA e. Pantothenic acid Which of the following statements about cholesterol metabolism is incorrect? Select one: O a. The carbon-backbone of cholesterol is derived from repeating units of acetyl-CoA. O b. Statins inhibit the enzyme that catalyses the first dedicated step of cholesterol biosynthesis. O c. Cells can synthesise cholesterol or acquire it through endocytosis of LDL particles. O d. In blood cholesterol is often transported as cholesterylester. Oe. Lecithin-cholesterol-acyl transferase (LCAT) is important for the release of cholesterol from VLDL particles

Explanation / Answer

(1)b.NADH

Fatty acid biosynthesis cofactor requirements include NADPH,ATP, Mn2+, biotin, and HCO3– (as a source of CO2).

(2)e.lecithin cholesterol acyltransferase is important for the release if cholesterol from VLDL particles.

All 27 carbon atoms of cholesterol are derived from acetyl CoA. Lecithin: cholesterol acyltransferase (LCAT) is a key enzyme which catalyzes the esterification of free cholesterol in plasma lipoproteins

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