Any if all? p53 causes the cessation of the cell cycle upor detection of DNA dam
ID: 259623 • Letter: A
Question
Any if all?
p53 causes the cessation of the cell cycle upor detection of DNA damage by causing expression p21, which leads to 17. The Cdk ihibito cdk4,6/Cyclin D complexes (thus inhibiting cak4,6/Cyclin D function). What would be predicted effect of overexpression of p16 on cycle progression? a) phosphorylation of chroma b) Transcription of DNA polymerase a Cells would be unable to enter M phase c) inhibition of Cdk4/6 d) Transcription of Chk1 and Chk2 cells would remain in the cell cycle, passing all checkpoints unregulated c. Cells would progress normally through the e) phosphorylation of Rb cell cycle d. Cells would be unable to exit the G, phase 12. The M phase checkpoint detects: a) the presence of MCM activity b) ending or completion of G2 phase c) chromosome alignment dichromosome alignment and attachment 18. The normal function of Rb is to a. induce apoptosis b. inhibit Ras of mitotic spindle c inhibit Cdkf.6/cyclin D d. inhibit E2 C inhibit progression to 5 phase upon e) spindle attachment of telomeres 13. What is required for an egg or sperm cell detection of DNA damage (eamete) to enter the cell cycle from GO? a) nutrients b) correct cell size 19. Would overexpression of p1G inhibit a tumo lacking functional Rb protein? growth factors d) all of the above e) none of the above a) YES NO 14. Crossing over between maternal and paternal chromosomes takes place during? al mitosis b) meiosis I 20. What DOES NOT happen during interphase in the cell cycle? fertilization d) meiosis II e) interphase DNA repair b)cell growth c) DNA duplication d)nuclear division e) normal cellular metäbolic activity 15. Crossing over occurs between? al paternal sister chromatids 21. Crossing over results in? bnonidentical sister chromatids ) Gametes b) New specles maternal sister chromatids d) nonhomologous chromosomes 16. In a cell with & chromosomes, how many total sister chromatids are visible at the beginning of New genetic combinations mitosis? b) B 16 25Explanation / Answer
11. p21 is an inhibitor of cdk-4,6 and does not allow cell to enter in cell cycle. Option c is correct.
12. M checkpoint detect the correct attachment of spindle to daughter chromatids before entering into anaphase. Option d is correct.
13. A cell has grown to certain size and require nutrients for energy production also growth factors to enter into divison. Option D is correct.
14 crossing over takes place during pachytene of prophase of Meiosis-I. Option B is correct.
15. Crossing over takes place between non-sister chromatids of the homologous chromosome pair. Option B is correct.
16. Cell will be having 32 chromatids because the chromosomes are doubled and 16 chromosomes before starting mitosis. Option D is correct.
17. Cdk inhibitor p16 protein inhibit the cdk protein and stop the cell to enter into S phase and arrest in G1 phase. Option D is correct.
18. Normally RB binds with Transcription factors of E2F and stop the cell divison.
19. RB is an protein which suppress the activity of cell divison. False.
20. Nuclear divison takes place in M phase. Option D.
21.Crossing over causes the recombination of the genetic material and causes the new genetic combination. Option C is correct.
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