Questions 7-10 refer to the properties of the CFTR protein (depicted below) asso
ID: 260691 • Letter: Q
Question
Questions 7-10 refer to the properties of the CFTR protein (depicted below) associated with cystic fibrosis. MSD-1 MSD-2 Extracellular Plasma ATP NBD-1 ATP NBD-2 ADP P ADP +P R domain PKA +ATP 7. How many transmembrane domains does the CFTR channel have? a.5 c.2 d.1 8. The CFTR protein is a transmembrane protein functioning in the cellular membranes of the lung epithelial cells. The "path" of CFTR from the place of its synthesis to its final destination is a. Cytoplasm, lysosome, cellular membrane b. Endoplasmic reticulum, cytoplasm, mitochondria, cellular membrane c. Cytoplasm, endoplasmic reticulum, Golgi apparatus, Cellular membrane d. Cytoplasm, Golgi apparatus, Endoplasmic reticulum, Cellular membrane 9. In an experiment you are applying an inhibitor of ATP hydrolysis to cells isolated from the epithelium of the internal surface of the lungs. The inhibitor stops all events of ATP hydrolysis in the cell. The most likely effect of this inhibitor on the function of the CFTR chlorine channel would be: a. CFTR will stop working b. CFTR will work better c. CFTR will work only with half of its capacity to transport chlorine d. no effect 10. The CFTR protein is a glycosylated protein. The sugar chains found in the molecule were most likely added in the a. Cytoplasmb. Mitochondria c. Lysosomes d. Golgi apparatusExplanation / Answer
7. CFTR is a glycoprotein of 1480 amino acid and consist of 5 domain.
Hence, option a is correct.
8 .The path is
Cytoplasm to ER to Golgi apparatus to cell membrane .Hence, option c is correct .
9. The most likely to forget that CFTR will stop working. Hence, option a is correct.
10 . The sugar chains will be added in the Golgi apparatus .
Hence, option d is correct .
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