Throughout life, the resting membrane potential of a neuron remains roughly cons

Question

Throughout life, the resting membrane potential of a neuron remains roughly constant at -65 mV.

1) In a mature neuron with an intracellular concentration of Chloride of 11 mM and an extracellular Chloride concentration of 110 mM, what would happen to membrane potential if a large number of Chloride channels opened? Would you expect that effect to be excitatory or inhibitory? Why is this?

2) Early in development, the intracellular Chloride concentration is higher than that found in mature neurons at 35 mM. During those early days, would increasing Chloride permeability be excitatory or inhibitory? Explain your answer and include relevant calculations.

Explanation / Answer

Throughout life, the resting membrane potential of a neuron remains roughly cons

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